The purpose of the work was to formulate fluoxetine hydrochloride orodispersible tablets with considerable increase in disintegration time; eight formulations were formulated and evaluated. Disintegration time of the tablet was improved with ludiflash, crospovidone, sodium starch glycolate and kyron T-314. The drug was characterized according to different compendium, on the basis of identification by UV spectroscopy, pH, organoleptic properties and other tests. Among the four disintegrating agents, one was selected for further studies i.e., ludiflash, because of more effectiveness and enhanced disintegration time. Tablets were prepared by direct compression method and effects of various processing parameters viz. Hardness, disintegration time and wetting time were studied to optimize disintegrating agent. Maximum concentration was obtained at drug-disintegrating agent ratio 1:8, drug concentration 20 mg. The values of pre-compression parameters evaluated, were within prescribed limits and indicated free flowing properties. Post-compression parameters such as hardness, thickness, uniformity of weight, friability, wetting time, water absorption ratio, in-vitro dispersion time, fineness of dispersion, in-vitro disintegration test, in-vitro drug release study, drug content uniformity were carry out. The batch F8 with disintegration time 19.02 sec±0.34 and dissolution 98.63% in 0.1N hydrochloric acid and 99.1% in pH 6.8 phosphate buffer was selected as optimized formulation. Batch F8 was also subjected to stability studies for one month and was tested for its % drug content, hardness, disintegration time and wetting time. It was observed no significant change in the contents of the tablets. By an appropriate selection and combination of excipients it was possible to obtain orodispersible tablets.
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